Timing5-HTP
Best before bed
When to take 5-HTP
Evening or before bed
5-HTP is a direct building block of serotonin, which the body later turns into melatonin. It's taken in the evening for mood and sleep.
Best time in your day
- Wake
- Workout
- Breakfast
- Lunch
- Evening
- Workout
- Dinner
- Walk
- Bed
- When
- Evening or before bed
- Food
- With or without food
- Typical dose
- 50–200 mg per day; start at 50 mg
How to take it
- 1Start at 50 mg in the evening
- 2Increase slowly
- 3Take it with a light snack if it causes nausea
- 4Don't use it long term without supervision
Watch out
Combining 5-HTP with serotonergic drugs can cause serotonin syndrome, which is dangerous. Never combine without medical advice.
Keep apart from
- Antidepressants (SSRIs, SNRIs, MAOIs)
- Triptans
- Tramadol
- St John's wort
Common questions
Can I take it with an antidepressant?
No, not without your doctor.
Does it help sleep?
It may help, since serotonin becomes melatonin.
Why does it cause nausea?
Serotonin in the gut affects nausea; start low.
Explore further
More timing guides
5-HTP with other supplements
SYNC check
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Build my routineFor general education only, not medical advice. Talk to a qualified doctor before starting or changing supplements, especially if you are pregnant, nursing or on medication.